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Formulation and Evaluation of Glipizide Solid Dispersion
M. R. Shivalingam, G. Durgabhavani, K. S. G. Arulkumaran
Livre broché | Anglais
63,45 €
+ 126 points
Description
More than 90% of the drugs arrowed since 1995 have poor solubility, poor permeability and more than 40% of new chemical entities have little or no water solubility. Glipizide is a class-II drug which is poorly soluble. So the solubility of the drug is enhanced by solid dispersion using solvent evaporation method. Drug and carrier in different ratios like 1: 1, 1: 2, 1: 3 by keeping drug weight constant. The prepared solid dispersions were evaluated for their routine tests like Phase solubility, Invitro dissolutoion study and the results were observed and tabulated. FT-IR study was also done for drug, polymers and 1: 3 ratios of drug: carrier by KBr pelleting method. From the study it was confirmed that no physical interactions were found. Also from the study it was concluded that 1: 3 ratio of drug:carrier shows better phase solubility and invitro dissolution rate.
Spécifications
Parties prenantes
- Auteur(s) :
- Editeur:
Contenu
- Nombre de pages :
- 84
- Langue:
- Anglais
Caractéristiques
- EAN:
- 9783659354366
- Date de parution :
- 26-02-13
- Format:
- Livre broché
- Dimensions :
- 150 mm x 220 mm
- Poids :
- 136 g
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+ 126 points sur votre carte client de Librairie Club
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