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Sulfonated Derivatives of 2,4-Xylidine: Possible Therapeutic Agents
Possible Therapeutic Agents
Muhammad Athar Abbasi, Sabahat Zahra Siddiqui
Livre broché | Anglais
40,95 €
+ 81 points
Description
Sulfonamides are considered to be pharmaceutically important class of compounds. In the present work, N-(2,4-dimethylphenyl)-4-toluenesulfonamide was synthesized by the reaction of 2,4-dimethylaniline and 4-tosyl chloride (4-methylbenzenesulfonyl chloride) using 10% aqueous Na2CO3 solution as reaction medium. At the second step, the synthesized molecule was made to react with different alkyl/aralkyl halides to yield the target compounds,using N,N-dimethylformamide (DMF) as reaction medium and lithium hydride as an activator. The synthesis of all the compounds was verified by spectral techniques using IR, 1H-NMR and EIMS; and further examined for their anti-enzymatic activities. The synthesized compounds represented the most potential against -glucosidase and lipoxygenase enzymes.
Spécifications
Parties prenantes
- Auteur(s) :
- Editeur:
Contenu
- Nombre de pages :
- 80
- Langue:
- Anglais
Caractéristiques
- EAN:
- 9783659636585
- Date de parution :
- 10-11-14
- Format:
- Livre broché
- Dimensions :
- 150 mm x 220 mm
- Poids :
- 127 g
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