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In this study, a recombinant non-pathogenic Pseudomonas putida KT2440 was applied for rhamnolipid or 3-(3-hydroxyalkanoyloxy)alkanoic acid production....Savoir plus
The environmental impact of plastic waste is regularly discussed. With bio-upcycling we can use plastic waste as a substrate for biotechnology. Polyme...Savoir plus
In the present thesis, a possible block in the sterol pathway to facilitate 2,3-oxidosqualene accumulation was investigated. Several truncated version...Savoir plus
Triterpenoids are plant secondary metabolites with wide application fields. Their production in microbial cell factories is a more advantageous altern...Savoir plus
To reduce the demand for fossil resources, biotechnological processes are increasingly applied. Hence, the used biological hosts have to be optimized ...Savoir plus
A novel microbial chassis from Paracoccus spp. was developed to support circular bioeconomy goals. A genetic toolbox enabling PET monomer utilization ...Savoir plus
This work describes the domestication of Pseudomonas species to produce various aromatic chemicals. The application of rational metabolic engineering ...Savoir plus
Reduced, valuable compounds can be produced using metabolically engineered microbes. The production of such molecules often relies on redox-cofactor-d...Savoir plus
The life expectancy of liver cirrhosis patients drastically worsens with decompensation. In this work, a clinical score was developed to identify pati...Savoir plus
Phosphate (Pi) is essential for all organisms and is typically minds from Pi-rock, which will be depleted in a few hundred years. In this thesis, Pi f...Savoir plus
Given the persistent growth in demand for food, energy, and chemicals in the coming decades, a shift from fossil-based raw materials to sustainable al...Savoir plus
Methyl ketones with a hydrocarbon chain length of C4 to C17 are currently produced from petrochemical resources, and there is only limited research on...Savoir plus
Poly-Gamma-glutamic acid (Gamma-PGA) is a biopolymer with various industrial applications. Despite its diverse applications, Gamma-PGA of defined mole...Savoir plus
Building a sustainable society requires moving beyond the linear produce-use-waste model reliant on fossil resources. A circular bioeconomy using CO2-...Savoir plus
Ginsenosides are triterpenoids, a class of natural products with many pharmaceutical functions, mainly present in traditional Chinese medicine Panax s...Savoir plus
Rhamnolipids and their precursors (HAAs) are promising sustainable biosurfactants and fuel intermediates. This work establishes recombinant production...Savoir plus
This dissertation advances the use of metabolic models for designing industrially relevant microbial cell factories. At the same time, the presented t...Savoir plus
While S. cerevisiae is one of the most used hosts in biotechnology, many aspects of its volatile metabolites are sparsely researched. This works aims ...Savoir plus
The burden posed on clinical care and drug development by adverse drug reactions is huge since current prediction methods often fail. In this work, co...Savoir plus
Establishing biotechnological processes within the envisaged circular bioeconomy requires the integration of all stages of process development. In thi...Savoir plus
Climate change is a pressing global issue that is caused by the consumption of fossil fuels. Cell factories are biological systems that are engineered...Savoir plus
Itaconic acid is of growing biotechnological significance due to its use for the production of bio-based polymers, chemicals, and novel fuels. By an i...Savoir plus
This thesis focused on the fungus Ustilago maydis as natural itaconic acid producer. Two strategies were chased to improve its production performance:...Savoir plus
Polymalate (PMA), a promising drug delivery system, can be produced by Aureobasidium pullulans NRRL 62031. The key genetic determinant for PMA polymer...Savoir plus